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Solid state research
Experimental solid-state R&D for the future of drug development

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Overview
Solid-state research services from pre-clinical to NDA

Our experimental services cover the entire spectrum of solid-state research, guiding projects from pre-clinical stages through to NDA filing. We focus on delivering a seamless and comprehensive drug development process, enhancing pharmaceutical R&D efficiency and ensuring success at every regulatory phase.
Research services

- Polymorph/Salt/Cocrystal screening & assessment
- Crystallization process development
- Solid dispersion formulation development
- Solid state characterization, & analytical method development
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Automated Solid Form Screening and Selection
R&D with solid-state chemistry screening platform
The intelligent automated solid-state screening platform transforms pharmaceutical R&D by integrating experimental techniques with automation. This approach reduces costs, boosts productivity, and accelerates the research and development process for faster results.



- Application scenarios
Comprehensive polymorph screening identifies and analyzes different crystal forms
Salt and co-crystal screening improves drug stability and solubility
Assessment of solid form developability includes evaluating solubility, stability, and hygroscopicity
Solid form analysis ensures intellectual property protection and supports regulatory submissions

Enhancement of drug bioavailability and key physicochemical properties
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Crystallization process development
Optimizing drug properties through crystallization process development
Crystallization process development enhances the properties of active pharmaceutical ingredients (APIs) by improving particle-size distribution, crystal morphology, bulk properties, and flowability. These improvements lead to better processability and dissolution of drugs, ensuring more efficient production and enhanced performance.
- Application scenarios
Scenarios 01
Improving Powder Properties
Powder properties are enhanced to improve drug performance and manufacturability.
Scenarios 02
Preparing Meta-Stable Forms
Meta-stable forms are prepared to optimize drug stability and efficacy.
Scenarios 03
Kilogram-Scale Crystallization
Crystallization processes are developed at kilogram scale to meet production demands.
- Key factors process

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Amorphous solid dispersion formulation development
Enhancing drug solubility with amorphous solid dispersion
Technologies like spray drying are used to disperse insoluble drugs in carrier polymer materials, improving solubility. These polymers are carefully screened to ensure the amorphous solid dispersion meets strict stability and dissolution performance standards, even at gram scale. This process enhances drug efficacy and ensures reliable production quality.