01
Drug Discovery

Robust Biology Capabilities to Accelerate Drug Discovery

Driving innovation in drug discovery with rapid bioassay developments, target protein preparation, and advanced screening technologies.

02
target protein preparation

Protein Expression and purification to enable assay development and structural biology studies

Preparing high-quality, custom-tagged proteins for specific assays.
Generating fresh protein complexes, including protein-ligand complexes for Cryo-EM studies.
03
Structural Biology

In-house Cryo-EM Technology to elucidate protein strcture and compound binding mode with high-resolution

Elucidate target protein 3D structures of complex biological macromolecules at atomic-level resolution.
Define compound binding modes enabling rational small molecule drug design.
Talos Glacios 200 kv equipped with Falcon IV (Glacios 300 kv accessible).
04
In vitro Bioassays

Bespoke enzymatic, cellular, and ADME assays for quick testing at scale

Biophysical assays using SPR, a label-free technology for diverse molecular interactions.
Biochemical assays include 50+ target-based assays at high throughput.
Cell-based assays with 100+ tumor cell lines, including lung, breast, ovarian, and gastric cancers.
In vitro ADMET services covering Caco-2, LMS, hERG, CYP inhibition, plasma-protein binding, and solubility.
05
In vivo Animal Efficacy Model Platform

Establish compound safety and efficacy profiles with in-house rodent DMPK and PK/PD studies, providing key insights for preclinical development

Perform comprehensive DMPK analysis to evaluate absorption, distribution, metabolism, and excretion, ensuring optimized safety and efficacy profiles for drug candidates.
PK/PD studies to assess dose-response relationships, guiding therapeutic dosing and refining compounds for clinical success

Your next success starts here

Harness the power of AI & Automation to discover new life-changing drugs, faster and more efficiently.

Search XtalPi

Development of small molecule selective inhibitors with XFEP
Discovery of Novel Non-covalent GPX4 Potent Hits with XFEP
Discovery of Novel Leads Targeting a Highly Flexible Allosteric Site with XMolGen and XFEP