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Solid state research

Crystal structure determination with SCXRD & MicroED

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MicroED (Microcrystal electron diffraction)

Revolutioning crystal structure analysis with automated MicroED platform

With over 100 successful analyses of small-molecule drugs, XtalPi continues to set new standards in crystallography, accelerating drug discovery & development.
XtalPi has revolutionized the field of crystallography with its state-of-the-art MicroED crystal structure analysis platform. This innovative tool, designed for high precision and speed, can determine crystal structures within just one day, eliminating the need for lengthy single crystal cultivation. Requiring only a minimal powder sample, the platform is not only efficient but also resource-effective.
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MicroED - Applications

Versatile applications of our crystallographic techniques

Determine crystal structures efficiently.
Identify salts and cocrystals accurately.
Confirm absolute configurations of molecules.
Qualitative structure analysis of mixture
Distinguish structural isomers effectively.
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MicroED - Facilities

Advanced MicroED facilities for precise results

Our MicroED facility is equipped with state-of-the-art instruments, including a Glacios 200 kV cryo-TEM from ThermoFisher Scientific, a specialized Ceta-D detector for MicroED, and a Falcon 4 direct electron detector. Paired with our vitrobot for rapid, precise sample preparation, these advanced tools enable us to perform high-quality research and deliver precise, reliable outcomes.

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MicroED - Technical Advantages

Advantages of MicroED

<1 mg
Minimal sample consumption
<1 day
Crystal structure determined
>95 %
High success rate
No cultivation
Single crystal cultivation not required
Chirality
Absolute configuration determination
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SCXRD (Single crystal X-Ray Diffraction)

SCXRD expertise for enhanced IP protection & IND/NDA filings

XtalPi offers specialized services in single crystal preparation and crystal structure determination via Single Crystal X-ray Diffraction (SCXRD).
Our precision-oriented approach supports intellectual property protection and facilitates the regulatory submission process for IND and NDA filings, ensuring that your pharmaceutical innovations meet compliance standards with detailed structural insights.
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services & Case Studies

Exploring techniques & case studies for crystal analysis

Breaking down MicroED & SCXRD methods

Play Video
Discover the distinctions and similarities between MicroED and SCXRD in crystal structure analysis. MicroED uses cryo-TEM and electron diffraction on crystalline powder, while SCXRD requires larger crystals and X-ray diffraction. Discover how each technique advances crystal structure resolution.

Unlocking MicroED in solid-state R&D

Play Video
Explore key steps in identifying and imaging micro-crystals and solving crystal structures. Dive into two case studies demonstrating how MicroED reveals detailed structures, like distinguishing salts from co-crystals by locating hydrogen atoms.

Ready to streamline your solid state research?

Contact us today, and discover how XtalGazer can revolutionize your drug discovery process.